柴田 勉

担当科目

バイオ

学位

農学博士（大阪府立大学）、農学修士（名古屋大学）

所属学会・団体

Global Enterprise Challenge 審査委員、グローバル人材・組織研究会代表

プロフィール

名古屋大学大学院農学研究科修了後、日本たばこ産業（株）安全性研究所毒性部門に配属。翌年に薬理部門に異動、東京大学医学部付属病院第三内科に出向。その後、医薬総合研究所生物研究所に配属。その間、抗糖尿病薬開発の業績にて大阪府立大学農学研究科博士課程を修了。その後、Tularik Pharmaceutical Company社（South San Francisco, CA）に駐在。帰国後、免疫学関係の医薬品開発に従事。東京本社開発企画部に異動後は臨床開発業務に従事し、Akros Pharma社（Princeton, NJ）に駐在。帰国後、プロジェクトリーダーとして医薬候補品のグローバル開発業務に従事。その後、経歴を活かし、次世代リーダー育成、組織開発業務に携わる。定年退職後、Learning Base AWAKEを主宰し、次世代グローバル人財育成に従事し現在に至る。

主な研究テーマ

グローバルに活躍できる日本人リーダーの育成

主な論文・実績等

論文発表
1. Shibata T., Takeuchi S., Yokota S., Kakimoto K., Yonemori F., Wakitani K., Effects of peroxisome proliferator-activated receptor- and - agonist, JTT-501, on diabetic complications in Zucker diabetic fatty rats, Br. J. Pharmacol. 130: 495-504 (2000)
2. Shibata T., Matsui K., Yonemori F., Wakitani K., Triglyceride-lowering effect of a novel insulin-sensitizing agent, JTT-501, Eur. J. Pharmacol. 373(1): 85-91 (1999)
3. Shibata T., Matsui K., Nagao K., Shinkai H., Yonemori F., Wakitani K., Pharmacological profiles of a novel oral antidiabetic agent, JTT-501, an isoxazolidinedione derivative, Eur. J. Pharmacol. 364(2-3): 211-219 (1999)
4. Shibata T., Matsui K., Yonemori F., Wakitani K., JTT-501, a novel oral antidiabetic agent, improves insulin resistance in genetic and non-genetic insulin-resistant models, Br. J. Pharmacol. 125: 1744-1750 (1998)
5. Maegawa H., Obata T., Shibata T., Fujita T., Ugi S., Morino K., Nishio Y., Kojima H., Hidaka H., Haneda M., Yasuda H., Kikkawa R., Kashiwagi A., _A new antidiabetic agent (JTT-501) rapidly stimulates glucose disposal rate enhancing insulin signal transduction in skeletal muscle, Diabetologia 42: 151-159 (1999)
6. Shinkai H., Onogi S., Tanaka M., Shibata T., Iwao M., Wakitani K., Uchida I., Isoxazolidine-3,5-dione and noncyclic 1,3-dicarbonyl compounds as hypoglycemic agents, J. Med. Chem. 41: 1927-1933 (1998)
7. Terasaki J., Anai M., Funaki M., Shibata T., Inukai K., Ogihara T., Ishihara H., Katagiri H., Onishi Y., Sakoda H., Fukushima Y., Yazaki Y., Kikuchi M., Oka Y., Asano T., Role of JTT-501, a new insulin sensitiser, in restoring impaired GLUT4 translocation in adipocytes of rats fed a high fat diet, Diabetologia 41: 400-409 (1998)
8. Miyagawa N., Iwasaki H., Kato T., Tanaka M., Shibata T., Wakitani K., Pharmacological analysis of antigen-induced late airway response in rats, Biol Pharm Bull 32: 394-398 (2009)
9. Miyagawa N., Iwasaki H., Kato T., Tanaka M., Shibata T., Wakitani K., Two pharmacological phases in antigen-induced immediate airway response in rats, Biol Pharm Bull 31: 2260-2264 (2008)
10. Miyagawa N., Iwasaki H., Kato T., Tanaka M., Shibata T., Wakitani K., Induction of late airway response was involved in serum antigen-specific immunoglobulin G in rats, Int Immunopharmacol 8: 1848-1853 (2008)
11. Nishiu J., Ito M., Ishida Y., Kakutani M., Shibata T., Matsushita M., Shindo M., JTP-426467 acts as a selective antagonist for peroxisome proliferator-activated receptor gamma in vitro and in vivo, Diabetes Obes Metab 8: 508-516 (2006)
12. Oda H., Suzuki Y., Shibata T., Yoshida A., Glucocorticoid-dependent induction of HMG-CoA reductase and malic enzyme gene expression by polychlorinated biphenyls in rat hepatocytes, J Nutr Biochem 10: 644-653 (1999)
13. Horio F., Shibata T., Makino S., Machino S., Hayashi Y., Hattori T., Yoshida A., UDP glucuronosyltransferease gene expression is involved in the stimulation of ascorbic acid biosynthesis by xenobiotics in rats, J Nutr 123: 2075-2084 (1993)
14. Horio F., Shibata T., Naito Y., Nishikimi M., Yagi K., Yoshida A., L-gulono-gamma-lactone oxidase is not induced in rats by xenobiotics stimulating L-ascorbic acid biosynthesis, J Nutr Sci Vitaminol 39: 1-9 (1993)
15. Ando I., Ogura N., Toyonaga Y., Hirahara K., Shibata T., Noguchi T., JTK-853, a novel non-nucleoside hepatitis C virus polymerase inhibitor, demonstrates a high genetic barrier to resistance in vitro, Intervirology 56(5): 302-9 (2013)
16. Ogura N., Toyonaga Y., Ando I., Hirahara K., Shibata T., Turcanu G., Pai S., Yee K., Gerhardt B., Rodriguez-Torres M., Noguchi T., Genotypic and phenotypic analyses of hepatitis C virus from patients treated with JTK-853 in a three-day monotherapy, Antimicrob Agents Chemother 57(1): 436-44 (2013)
学会発表（直近5年のみ）
17. Rodriguez-Torres M., Pai S., Gerhardt B., Yamada H., Yee K., Shibata T., Turcanu G., Ogura N., Toyonaga Y., Noguchi T., Antiviral activity, safety and pharmacokinetics of JTK-853, a novel non-nucleoside polymerase inhibitor, in a 3-day proof-of-concept study in HCV genotype 1 patients, and evaluation of emergence of resistance, Hep dart (2013)
18. Pai S., Gerhardt B., Hunt T., Yamada H., Yee K., Shibata T., Pharmacokinetics, safety, tolerability of JTK-853, a novel non-nucleoside HCV polymerase inhibitor, following single and repeated twice-daily administration for 14 days to healthy volunteers, Hep dart (2013

関連URL

ー